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KMID : 0380620110430060787
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Korean Journal of Food Science and Technology
2011 Volume.43 No. 6 p.787 ~ p.790
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Effect of Acer tegmentosum M. Extracts on Hepatocarcinoma Cell
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Kwon Ha-Na
Bang Woo-Suk
Kim Joo-Young
Park Jyung-Rewng
Jeon Jeong-Ryae
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Abstract
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The objective of this study was to investigate the anticancer effects of Acer tegmentosum M. extracts. HepG2 hepatocarcinoma cells were treated with ethanol, chloroform, ethylacetate, butanol, aqueous fraction and hot water extract. The antiproliferative effect was evaluated by trypan blue exclusion, MTT-based viability assay and morphology. The trypan blue test showed that anticancer effect of the A. tegmentosum M. extracts on HepG2 cells increased gradually in proportion to the increasing concentration of the fractions. The butanol fraction showed the highest anticancer activity against HepG2 cells (p<0.05). The MTT assay indicated that the growth inhibition by the butanol fraction was dose-dependent. These results suggest that A. tegmentosum M. has the potential to inhibit the growth of hepatocarcinoma cells.
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KEYWORD
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Acer tegmentosum M., HepG2 hepatocarcinoma cell, MTT assay, anticancer
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